Alexander A Makarov Selected Research

ribonuclease T(2)

9/2017	Binase treatment increases interferon sensitivity and apoptosis in SiHa cervical carcinoma cells by downregulating E6 and E7 human papilloma virus oncoproteins.
7/2013	Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells.
12/2011	Sensitivity of acute myeloid leukemia Kasumi-1 cells to binase toxic action depends on the expression of KIT and АML1-ETO oncogenes.
10/2007	Binase induces apoptosis of transformed myeloid cells and does not induce T-cell immune response.

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Alexander A Makarov Research Topics

Disease

34	Alzheimer Disease (Alzheimer's Disease) 03/2022 - 01/2008
7	Neoplasms (Cancer) 12/2021 - 06/2007
6	Amyloid Plaque 12/2021 - 04/2011
5	Hypoxia (Hypoxemia) 01/2019 - 09/2012
4	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2022 - 04/2011
3	Infections 01/2021 - 05/2015
3	Neuroblastoma 01/2019 - 01/2016
3	Amyloidosis 01/2018 - 05/2016
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2014 - 07/2010
2	Vascular Diseases (Vascular Disease) 01/2021 - 01/2020
2	Leukemia 12/2011 - 12/2007
1	Genomic Instability 01/2022
1	Neuroinflammatory Diseases 12/2021
1	Hypertension (High Blood Pressure) 12/2021
1	Heart Diseases (Heart Disease) 12/2021
1	Memory Disorders (Memory Loss) 08/2021
1	HIV Infections (HIV Infection) 01/2020
1	Chronic Disease (Chronic Diseases) 01/2020
1	Cognitive Dysfunction 01/2020
1	Sudden Infant Death (SID) 01/2019
1	Atherosclerosis 01/2018
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/2017
1	Carcinoma (Carcinomatosis) 09/2017
1	Virus Diseases (Viral Diseases) 01/2016
1	Hepatocellular Carcinoma (Hepatoma) 05/2015
1	Melanoma (Melanoma, Malignant) 07/2013
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 07/2013
1	Neoplasm Metastasis (Metastasis) 07/2013
1	Lewis Lung Carcinoma 07/2013
1	Pathologic Processes 03/2012

Drug/Important Bio-Agent (IBA)

23	Amyloid (Amyloid Fibrils)IBA 12/2021 - 07/2008
21	Peptides (Polypeptides)IBA 12/2021 - 07/2008
10	Amyloid beta-PeptidesIBA 03/2022 - 01/2008
10	ZincIBA 01/2020 - 07/2008
7	Proteins (Proteins, Gene)FDA Link 08/2021 - 05/2015
6	IonsIBA 01/2020 - 01/2012
4	Adenosine Triphosphatases (ATPase)IBA 01/2019 - 01/2016
4	Ribonucleases (Ribonuclease)IBA 09/2017 - 06/2007
4	ribonuclease T(2)IBA 09/2017 - 10/2007
3	CholesterolIBA 01/2021 - 01/2018
3	MetalsIBA 11/2016 - 01/2012
2	LigandsIBA 08/2021 - 01/2019
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2020 - 01/2019
2	Cholinergic Agents (Cholinergics)IBA 08/2020 - 01/2019
2	Histidine (L-Histidine)FDA Link 01/2020 - 02/2016
2	Glutathione Disulfide (GSSG)FDA LinkGeneric 01/2019 - 10/2017
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 10/2018 - 01/2018
2	Carrier Proteins (Binding Protein)IBA 01/2018 - 12/2014
2	EnzymesIBA 10/2017 - 01/2016
2	SolutionsIBA 09/2015 - 01/2012
1	Nerve Growth Factors (Neurotrophins)IBA 01/2022
1	SenotherapeuticsIBA 01/2022
1	Antifibrotic AgentsIBA 01/2022
1	PrebioticsIBA 01/2022
1	Immunologic Factors (Immunomodulators)IBA 01/2022
1	AcidsIBA 12/2021
1	Antiviral Agents (Antivirals)IBA 12/2021
1	Antimicrobial PeptidesIBA 10/2020
1	Adenosine Monophosphate (AMP)IBA 10/2020
1	AntibodiesIBA 07/2020
1	Laminin (Merosin)IBA 07/2020
1	LipidsIBA 01/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	UbiquitinIBA 01/2019
1	Biological ProductsIBA 01/2019
1	S-ethyl glutathioneIBA 01/2019
1	Sulfhydryl Compounds (Thiols)IBA 01/2019
1	S-NitrosoglutathioneIBA 01/2019
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2019
1	Arginine (L-Arginine)FDA Link 10/2018
1	EndopeptidasesIBA 10/2018
1	Aspartic Acid (Aspartate)FDA Link 02/2018
1	thioflavin TIBA 01/2018
1	Trace Elements (Biometals)IBA 01/2018
1	Cysteine (L-Cysteine)FDA Link 10/2017
1	Cardiac GlycosidesIBA 10/2017
1	Oncogene Proteins (Oncogene Protein)IBA 09/2017
1	InterferonsIBA 09/2017
1	Viral ProteinsIBA 09/2017
1	polyprolineIBA 09/2017
1	Protein AggregatesIBA 09/2016
1	src-Family KinasesIBA 01/2016
1	PotassiumIBA 01/2016
1	SodiumIBA 01/2016
1	Nucleocapsid ProteinsIBA 05/2015
1	IsatinIBA 12/2014
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 12/2014
1	ribonuclease Sa3IBA 01/2014
1	Caspase 8 (Caspase-8)IBA 07/2013
1	Adenosine Triphosphate (ATP)IBA 09/2012
1	tau Proteins (tau Protein)IBA 03/2012
1	Toxic ActionsIBA 12/2011
1	Protein Isoforms (Isoforms)IBA 04/2011
1	Pharmaceutical PreparationsIBA 04/2011
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 07/2010

Therapy/Procedure

5	Therapeutics 03/2022 - 06/2007
2	Intravenous Injections 01/2018 - 05/2016
2	Intraperitoneal Injections 05/2016 - 07/2013
1	Highly Active Antiretroviral Therapy (HAART) 01/2020
1	Injections 01/2018